Buffers and salts are integral to biopharmaceutical downstream processing, making up the largest volume of materials used in manufacturing. To meet the complex demands of processes like ultrafiltration/diafiltration (UF/DF) in monoclonal antibody (mAbs) production, efficient and reliable buffer delivery systems are essential. Avantor’s Inline Buffer Dilution System offers a game-changing solution for simplifying buffer preparation and delivery.
The Need for Innovation in Buffer Management
Traditional buffer preparation requires large holding vessels and extensive infrastructure, increasing costs, labor, and facility footprint. With inline buffer dilution, these challenges are addressed by enabling precise mixing and on-demand delivery of buffers directly to the process line. This approach eliminates the need for pre-mixed bulk buffers, offering flexibility and efficiency while maintaining the high-quality standards required for cGMP manufacturing.
Key Features of the Avantor Inline Buffer Dilution System
Compact Design for Efficiency:
Built with 304 stainless steel cabinetry and a small footprint, the system is designed to optimize space and streamline workflow. Its single-use components are pre-validated and ready to use, minimizing setup time.
Precision and Control:
The inline static mixer ensures accurate buffer preparation with real-time pH and conductivity monitoring. This guarantees consistent quality, while the discharge feature automatically removes out-of-specification material.
Customizable for Process Needs:
With batch programmability, the system offers lot-to-lot consistency. It supports common buffers like PBS, Tris-HCl, and NaOH, as well as customized proprietary solutions developed by Avantor’s expert team.
Enhanced Process Parameters:
Dilution rate: 0.7–10.0 L/min
Operating temperature: 4–50°C
Conductivity range: 0.1–100 mS/cm
Single-Use Technology:
All fluid pathways are single-use, gamma-irradiated, and certified to USP standards, ensuring sterility and compliance with regulatory requirements.
Benefits of Inline Buffer Dilution
Time and Cost Savings:
Reduces labor associated with traditional buffer prep.
Decreases batch preparation time.
Minimizes infrastructure requirements, such as large holding vessels.
Improved Quality and Safety:
Consistent and reproducible buffer formulations.
Reduced operator exposure to chemicals.
Enhanced regulatory compliance with 21 CFR Part 11 software.
Supply Chain Security:
Vertically integrated manufacturing for robust supply.
Streamlined inventory management through centralized buffer concentrate sourcing.
Partnering for Success
Avantor brings its expertise in chemical manufacturing, single-use technologies, and custom solution design to help biopharma companies overcome bottlenecks in buffer preparation. By adopting the Inline Buffer Dilution System, manufacturers can focus on their core processes while reducing costs, saving time, and increasing operational flexibility.
Explore the Avantor Advantage
Contact your Avantor representative to learn more about how the Inline Buffer Dilution System can optimize your downstream processing. Visit Avantor’s website or the National Institute for Bioprocessing Research & Training (NIBRT) to see the system in action.
This system is an essential step toward modernizing buffer management, empowering biopharma manufacturers to scale efficiently and maintain the highest quality standards.