Simplifying LC-MS Analysis with HiPerSolv CHROMANORM®: Solvents, Additives, and Essential Tools

Liquid Chromatography-Mass Spectrometry (LC-MS) is a cornerstone analytical technique, offering unparalleled sensitivity and specificity. However, achieving consistent and reliable results often hinges on using the right solvents, additives, and accessories. HiPerSolv CHROMANORM® and VWR deliver a comprehensive range of LC-MS products, making it easier for researchers to meet the demands of modern analytical workflows.

1. HiPerSolv CHROMANORM® LC-MS and Ultra LC-MS Solvents

Crafted for precision, HiPerSolv CHROMANORM® LC-MS solvents are designed to meet the stringent requirements of LC-MS and ULC-MS applications. Key features include:

Low Ionic Background: Reduces noise for clearer baselines.

Minimal Alkaline Metal Content: Max. 100 ppb, with many metals below 20 ppb for Ultra LC-MS grades.

High UV Transmission: Ensures minimal interference.

Very Low Residue and Water Content: Maintains sample integrity.

Filtered at 0.2 μm and Bottled Under Nitrogen: Prevents contamination.

PTFE-Lined Caps: Enhances long-term stability and purity.

These specifications make these solvents ideal for high-performance and ultra-sensitive LC-MS analyses, including UPLC and UHPLC applications.

2. LC-MS Grade Additives: Enhancing Analyte Ionization

Additives are indispensable for improving analyte ionization and chromatographic separations. HiPerSolv CHROMANORM® offers high-quality additives, such as:

Trifluoroacetic Acid (TFA): Optimizes peak resolution and controls pH, ideal for proteins and peptides.

Ammonium Acetate/Formate: Neutral volatile salts that stabilize separations under neutral conditions.

Benefits of using these additives include:

Improved Signal Quality: Enhances ionization efficiency.

Suppression of Unwanted Signals: Provides selective enhancement for target compounds.

Optimal Retention and Peak Shape: Ensures reliable separations under various pH conditions.

3. LC-MS Grade Mixes: Time-Saving Precision

Pre-blended LC-MS mobile phase solutions eliminate the hassle of manual preparation, reducing errors and downtime. These mixes are:

Accurately Composed: Ensures consistent results.

Minimizes Baseline Noise and Artifacts: Supports high-sensitivity analyses.

Ready-to-Use: Saves valuable time in busy laboratories.

4. Safety Caps: Protecting Analysts and the Environment

Handling volatile solvents can pose health and safety challenges. Safety Caps from VWR address these concerns by:

Preventing Solvent Evaporation: Reduces exposure to harmful vapors.

Ensuring Accurate Solvent Composition: Maintains the integrity of mobile phases.

Chemically Resistant: Suitable for aggressive organic solvents.

Additional features include an air valve and filter valve, which should be replaced every six months to ensure maximum safety and performance.

5. LC-MS Certified Acrodisc® Syringe Filters

Acrodisc® MS syringe filters minimize interference and protect instruments from contamination. Key advantages:

Low Extractables: Reduces ion suppression/enhancement.

Chemical Resistance: Compatible with a wide range of solvents.

Particulate Retention: Extends the life of columns and instruments.

6. LC-MS and GC-MS Certified Vial Kits

Vials and closures are critical for maintaining sample purity and preventing contamination. VWR’s certified vial kits feature:

Low Adsorption Properties: Ideal for polar compounds.

Ultra-Low Bleed Silicone Septum: Optimized for ultra-trace analysis.

Batch-Specific Test Certificates: Provides assurance of quality and purity.

Supporting Seamless LC-MS Operations

From solvents to accessories, VWR’s extensive range of LC-MS products ensures accurate, reproducible, and efficient analyses. Explore the full product range and enhance your analytical capabilities by visiting VWR Chromatography Solutions.