Liquid Chromatography-Mass Spectrometry (LC-MS) is a cornerstone analytical technique, offering unparalleled sensitivity and specificity. However, achieving consistent and reliable results often hinges on using the right solvents, additives, and accessories. HiPerSolv CHROMANORM® and VWR deliver a comprehensive range of LC-MS products, making it easier for researchers to meet the demands of modern analytical workflows.
1. HiPerSolv CHROMANORM® LC-MS and Ultra LC-MS Solvents
Crafted for precision, HiPerSolv CHROMANORM® LC-MS solvents are designed to meet the stringent requirements of LC-MS and ULC-MS applications. Key features include:
Low Ionic Background: Reduces noise for clearer baselines.
Minimal Alkaline Metal Content: Max. 100 ppb, with many metals below 20 ppb for Ultra LC-MS grades.
High UV Transmission: Ensures minimal interference.
Very Low Residue and Water Content: Maintains sample integrity.
Filtered at 0.2 μm and Bottled Under Nitrogen: Prevents contamination.
PTFE-Lined Caps: Enhances long-term stability and purity.
These specifications make these solvents ideal for high-performance and ultra-sensitive LC-MS analyses, including UPLC and UHPLC applications.
2. LC-MS Grade Additives: Enhancing Analyte Ionization
Additives are indispensable for improving analyte ionization and chromatographic separations. HiPerSolv CHROMANORM® offers high-quality additives, such as:
Trifluoroacetic Acid (TFA): Optimizes peak resolution and controls pH, ideal for proteins and peptides.
Ammonium Acetate/Formate: Neutral volatile salts that stabilize separations under neutral conditions.
Benefits of using these additives include:
Improved Signal Quality: Enhances ionization efficiency.
Suppression of Unwanted Signals: Provides selective enhancement for target compounds.
Optimal Retention and Peak Shape: Ensures reliable separations under various pH conditions.
3. LC-MS Grade Mixes: Time-Saving Precision
Pre-blended LC-MS mobile phase solutions eliminate the hassle of manual preparation, reducing errors and downtime. These mixes are:
Accurately Composed: Ensures consistent results.
Minimizes Baseline Noise and Artifacts: Supports high-sensitivity analyses.
Ready-to-Use: Saves valuable time in busy laboratories.
4. Safety Caps: Protecting Analysts and the Environment
Handling volatile solvents can pose health and safety challenges. Safety Caps from VWR address these concerns by:
Preventing Solvent Evaporation: Reduces exposure to harmful vapors.
Ensuring Accurate Solvent Composition: Maintains the integrity of mobile phases.
Chemically Resistant: Suitable for aggressive organic solvents.
Additional features include an air valve and filter valve, which should be replaced every six months to ensure maximum safety and performance.
5. LC-MS Certified Acrodisc® Syringe Filters
Acrodisc® MS syringe filters minimize interference and protect instruments from contamination. Key advantages:
Low Extractables: Reduces ion suppression/enhancement.
Chemical Resistance: Compatible with a wide range of solvents.
Particulate Retention: Extends the life of columns and instruments.
6. LC-MS and GC-MS Certified Vial Kits
Vials and closures are critical for maintaining sample purity and preventing contamination. VWR’s certified vial kits feature:
Low Adsorption Properties: Ideal for polar compounds.
Ultra-Low Bleed Silicone Septum: Optimized for ultra-trace analysis.
Batch-Specific Test Certificates: Provides assurance of quality and purity.
Supporting Seamless LC-MS Operations
From solvents to accessories, VWR’s extensive range of LC-MS products ensures accurate, reproducible, and efficient analyses. Explore the full product range and enhance your analytical capabilities by visiting VWR Chromatography Solutions.